Endocrine Abstracts

The capacity of microRNAs (miRNAs) to simultaneously repress multiple targets provide a mechanism to treat disease by modulating entire biological networks. miRNAs are present in the systemic circulation and other biological fluids associated with extracellular microvesicles, exosomes, Ago2 complex or HDL. Even exogenous miRNAs have been described in our circulation. The active secretion of miRNAs by the cells has been suggested to mediate intercellular communication. The inte...